Purinergic P2Y6 receptors in cardiovascular stress resistance
نویسندگان
چکیده
منابع مشابه
Purinergic P2Y6 receptors heterodimerize with angiotensin AT1 receptors to promote angiotensin II-induced hypertension.
The angiotensin (Ang) type 1 receptor (AT1R) promotes functional and structural integrity of the arterial wall to contribute to vascular homeostasis, but this receptor also promotes hypertension. In our investigation of how Ang II signals are converted by the AT1R from physiological to pathological outputs, we found that the purinergic P2Y6 receptor (P2Y6R), an inflammation-inducible G protein ...
متن کاملPurinergic receptors in human placenta: evidence for functionally active P2X4, P2X7, P2Y2, and P2Y6.
Appropriate regulation of ion transport by the human placental syncytiotrophoblast is important for fetal growth throughout pregnancy. In nonplacental tissues, ion transport can be modulated by extracellular nucleotides that raise intracellular calcium ([Ca2+]i) via activation of purinergic receptors. We tested the hypothesis that purinergic receptors are expressed by human placental cytotropho...
متن کاملPurinergic Receptors in Ocular Inflammation
Inflammation is a complex process that implies the interaction between cells and molecular mediators, which, when not properly "tuned," can lead to disease. When inflammation affects the eye, it can produce severe disorders affecting the superficial and internal parts of the visual organ. The nucleoside adenosine and nucleotides including adenine mononucleotides like ADP and ATP and dinucleotid...
متن کاملPurinergic receptors in the rat lens: activation of P2X receptors following hyperosmotic stress.
PURPOSE A range of P2Y and P2X receptors is expressed in the rat lens. Because most P2X receptors are located in the cytoplasm, the authors sought to determine whether P2X receptors are functionally active. METHODS Rat lenses were cultured under either isotonic or hypertonic conditions in the presence of P2 receptor agonists or antagonists. Lenses were fixed and cryosectioned, cell membranes ...
متن کاملPurinergic receptors and pain.
There is a brief summary of the early background literature about purinergic signalling and its involvement in pain, of ATP storage, release and ectoenzymatic breakdown and of the current classification of receptor subtypes for purines and pyrimidines. The review then focuses on purinergic mechanosensory transduction involved in visceral, cutaneous and musculoskeletal nociception and on the rol...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings for Annual Meeting of The Japanese Pharmacological Society
سال: 2018
ISSN: 2435-4953
DOI: 10.1254/jpssuppl.wcp2018.0_sy57-3